The global Netupitant - Palonosetron FDC sales are expected to reach USD 515.0 million by 2018. The global Chemotherapy-induced nausea and vomiting (CINV) market is estimated to reach USD 1.7 billion by 2015 at a growth rate of 7.1%, whereas country such as South Africa is estimated to constitute 9% of the CINV market by 2015, due to prevalent cancer related conditions and subsequent increase in CINV patient pool. Asian region is expected to witness largest patient share for CINV contributing majorly to the total CINV patient pool. Hence, Asian market is expected to have huge growth potential for Netupitant - Palonosetron FDC.
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Chemotherapy is one of the treatment options utilized by oncologists in treating different types of cancers. Nausea and vomiting are the most common side-effects experienced by cancer patients when administered with chemotherapy. Netupitant-palonosetron, which is currently in Phase III trials helps in preventing CINV. The blockage of P/NK1 receptors by Netupitant in the central nervous system inhibits the binding of endogenous tachykinin neuropeptide substance and this result in preventing the chemotherapy-induced nausea and vomiting. Moreover, Palonosetron helps in the blockage of serotonin at 5-hydroxytryptamine type 3 (5-HT3) receptors and it also helps in the chemotherapy-induced nausea and vomiting.
Netupitant-Palonosetron FDC is estimated to answer significant unmet needs of the CINV market post its launch that is expected to be commercialized in 2014, as it would overcome the problems associated with current treatment with 5-HT3 receptor antagonists. Similar to Emend, Netupitant-Palonosetron FDC would gain considerable patient pool after its estimated launch in 2014, and subsequently match the patient share of Aloxi by 2018. Netupitant-Palonosetron FDC sales are expected to reach an estimated USD 515.0 million USD by 2018. FDC combination of 5-HT3 receptor antagonist and neurokinin-1 (NK1) receptor antagonist have shown better efficacy results in Phase II clinical trials for CINV patients and would thus lead to high uptake due to shifting physician and patient preference pattern towards better treatment for CINV.
The lack of approval to any other antagonist for the prevention of delayed-onset CINV in patients getting highly emetogenic chemotherapy, Palonosetron is expected to witness higher growth. It is expected to grow at a higher rate during the forecasted period in both developed and developing regions such as South Africa and Asia among others.
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CINV can cause cancer patients to withdraw from therapy due to increased medical costs, often leading to higher mortality and higher medical spending. So, patients and providers would realize the benefits of finding alternative CINV therapies, such as Netupitant-Palonosetron FDC.
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New entrants to this market have historically benefited from rapid uptake, driven both by clinical advantages and by favorable reimbursement dynamics, from which Netupitant-Palonosetron FDC is poised to benefit upon approval.
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There is certain advantage of the Netupitant - Palonosetron as it would be the only FDC approved for treating chemotherapy induced nausea and vomiting that is likely to drive this market in the near future. Moreover, it is effective in the body for longer period of time and will help in achieving better patient compliance. However, lack in the number of clinical trials is likely to slower the growth of this market but the rising cancer population is likely to further create an opportunity in this market.
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